A Receptor for All Occasions.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26871625.
- Also identified by DOI 10.1016/j.cell.2016.01.030.
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Abstract
Cells communicate with their environment, in part, through cell surface receptors. Engineering receptors that both sense arbitrary inputs and provide outputs orthogonal to endogenous signaling pathways has been a challenge. Now, Lim and colleagues report a system based on synthetic Notch receptors that allows independent control of both inputs and outputs in diverse cell types.
Medical subject headings
- Cell Engineering
- Immunotherapy
- Neoplasms
- Receptors, Notch
- Signal Transduction
- Synthetic Biology
- T-Lymphocytes