A New Way to Diversify Antibodies by DNA Transposition.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26871626.
- Also identified by DOI 10.1016/j.cell.2016.01.031.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
While searching for new therapeutics against malaria, Lanzavecchia and colleagues discovered that antibodies can be diversified by DNA sequences encoded outside of antibody genes.
Medical subject headings
- Antibodies, Monoclonal
- Antibody Specificity
- Antigenic Variation
- Antigens, Protozoan
- Malaria
- Mutagenesis, Insertional
- Plasmodium falciparum
- Receptors, Immunologic