The Cellular Phase of Alzheimer's Disease.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 26871627.
- Also identified by DOI 10.1016/j.cell.2015.12.056.
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Abstract
The amyloid hypothesis for Alzheimer's disease (AD) posits a neuron-centric, linear cascade initiated by Aβ and leading to dementia. This direct causality is incompatible with clinical observations. We review evidence supporting a long, complex cellular phase consisting of feedback and feedforward responses of astrocytes, microglia, and vasculature. The field must incorporate this holistic view and take advantage of advances in single-cell approaches to resolve the critical junctures at which perturbations initially amenable to compensatory feedback transform into irreversible, progressive neurodegeneration.
Medical subject headings
- Alzheimer Disease