Bioinspired Alkenyl Amino Alcohol Ionizable Lipid Materials for Highly Potent In Vivo mRNA Delivery.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26889757.
- Also identified by DOI 10.1002/adma.201505822 and PMC identifier 5245883.
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Abstract
Thousands of human diseases could be treated by selectively controlling the expression of specific proteins in vivo. A new series of alkenyl amino alcohol (AAA) ionizable lipid nanoparticles (LNPs) capable of delivering human mRNA with unprecedented levels of in vivo efficacy is demonstrated. This study highlights the importance of utilizing synthesis tools in tandem with biological inspiration to understand and improve nucleic acid delivery in vivo.
Medical subject headings
- Alkenes
- Amino Alcohols
- Biomimetic Materials
- Drug Carriers
- Lipids
- Nanoparticles