Influence of Respiratory Position on Contrast Attenuation in Pulmonary CT Angiography: A Prospective Randomized Clinical Trial.

Abstract

The purpose of this study was to prospectively compare the effect of inspiration and resting expiratory position on contrast enhancement in pulmonary CT angiography (CTA) in a randomized clinical trial. In accordance with a power analysis performed before the study, we included 28 consecutive patients referred for evaluation of suspected pulmonary embolism in this prospective study. Patients were randomly assigned to perform either inspiration (n = 14; six men, eight women; mean age [SD], 38.1 ± 9.8 years) or resting expiratory position (n = 14; six men, eight women; mean age: 42.1 ± 9.2 years). All patients were scanned in a standardized supine position and scanning parameters were kept constant. Contrast medium was injected automatically with bolus tracking. Objective pulmonary vessel attenuation was quantified with digital measurement. Results were analyzed by using the unpaired t test and chi-square test. Patients in the resting expiratory position showed significantly higher contrast attenuation than those who performed inspiration (302.9 ± 11.9 HU vs 221.5 ± 20.9 HU; p < 0.01). There were no significant differences in applied total volume of contrast agent (76.8 ± 1.9 mL vs 75.7 ± 1.6 mL; p = 0.6765), total volume including normal saline bolus (116.8 mL ± 2.8 mL vs 121.8 mL ± 2.3 mL; p = 0.1724) or flow rate (3.1 mL/s ± 0.1 mL/s vs 3.2 mL/s ± 0.1 mL/s). Pulmonary CTA should be performed in the resting expiratory position, and patients should be instructed to avoid inspiration to achieve the highest possible attenuation in the pulmonary arteries.