2D Representation of Transcriptomes by t-SNE Exposes Relatedness between Human Tissues.
Where this comes from
- Record sourced from PubMed, PMID 26906061.
- Also identified by DOI 10.1371/journal.pone.0149853 and PMC identifier 4764374.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The GTEx Consortium reported that hierarchical clustering of RNA profiles from 25 unique tissue types among 1641 individuals accurately distinguished the tissue types, but a multidimensional scaling failed to generate a 2D projection of the data that separates tissue-subtypes. In this study we show that a projection by t-Distributed Stochastic Neighbor Embedding is in line with the cluster analysis which allows a more detailed examination and visualization of human tissue relationships.
Medical subject headings
- Databases, Genetic
- Transcriptome