A Happy 3' Ending to the piRNA Maturation Story.
basic_science · Level V
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- Record sourced from PubMed, PMID 26919421.
- Also identified by DOI 10.1016/j.cell.2016.02.012.
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Abstract
For a decade, mystery has surrounded the mechanisms by which piRNA biogenesis yields distinct size classes of small RNAs within individual PIWI proteins. In this issue of Cell, two studies shed light on this process, identifying conserved PARN-family exonucleases that trim piRNAs to their mature size in silkworms and C. elegans.