EMT: Matter of Life or Death?
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26919422.
- Also identified by DOI 10.1016/j.cell.2016.02.024.
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Abstract
TGF-β is long considered a "protean" cytokine in cancer, changing its role from anti- to pro-tumorigenic in a context-dependent manner. In this issue of Cell, David et al. use mouse models of pancreatic cancer to shed light on the mechanistic basis of how TGF-β-induced EMT is coupled to either apoptosis or tumor progression.
Medical subject headings
- Carcinoma, Ductal
- Epithelial-Mesenchymal Transition
- Gene Regulatory Networks
- Pancreatic Neoplasms
- Transforming Growth Factor beta