Ground Control to Major Tom: The Cell Body Signals Axon Degeneration.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 26919423.
- Also identified by DOI 10.1016/j.cell.2016.02.013.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Axon degeneration in response to trophic deprivation was thought to be locally restricted to the axon. However, increasing evidence points to a requirement for the cell body in the degenerative program. Now, Simon et al. identify the pro-apoptotic protein Puma as a key factor in this cell body-derived signal.
Medical subject headings
- Axons
- Neurons
- Signal Transduction