Multigrowth Factor Delivery via Immobilization of Gene Therapy Vectors.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26919685.
- Also identified by DOI 10.1002/adma.201600027 and PMC identifier 5687504.
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Abstract
Molecules can be immobilized onto biomaterials by a chemical vapor deposition (CVD) coating strategy. Pentafluorophenolester groups react with amine side chains on antibodies, which can selectively immobilize adenoviral vectors for gene delivery of growth factors. These vectors can produce functional proteins within defined regions of biomaterials to produce customizable structures for targeted tissue regeneration.
Medical subject headings
- Adenoviridae
- Antibodies, Immobilized
- Biocompatible Materials
- Gene Transfer Techniques
- Genetic Therapy
- Genetic Vectors
- Intercellular Signaling Peptides and Proteins