SuReSim: simulating localization microscopy experiments from ground truth models.
basic_science · Level V
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- Record sourced from PubMed, PMID 26928761.
- Also identified by DOI 10.1038/nmeth.3775.
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Abstract
Super-resolution fluorescence microscopy has become a widely used tool in many areas of research. However, designing and validating super-resolution experiments to address a research question in a technically feasible and scientifically rigorous manner remains a fundamental challenge. We developed SuReSim, a software tool that simulates localization data of arbitrary three-dimensional structures represented by ground truth models, allowing users to systematically explore how changing experimental parameters can affect potential imaging outcomes.
Medical subject headings
- Image Processing, Computer-Assisted
- Imaging, Three-Dimensional
- Microscopy, Fluorescence
- Software
- Synaptic Vesicles