Microneedles Integrated with Pancreatic Cells and Synthetic Glucose-Signal Amplifiers for Smart Insulin Delivery.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26928976.
- Also identified by DOI 10.1002/adma.201506025 and PMC identifier 4998837.
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Abstract
An innovative microneedle (MN)-based cell therapy is developed for glucose-responsive regulation of the insulin secretion from exogenous pancreatic β-cells without implantation. One MN patch can quickly reduce the blood-sugar levels (BGLs) of chemically induced type-1 diabetic mice and stabilize BGLs at a reduced level for over 10 h.
Medical subject headings
- Blood Glucose
- Diabetes Mellitus, Experimental
- Insulin
- Islets of Langerhans
- Needles