Low dose aspirin and pregnancy: how important is aspirin resistance?
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 26929162.
- Also identified by DOI 10.1111/1471-0528.13914 and PMC identifier 5069612.
- Licence recorded as CC BY-NC-ND.
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Abstract
Antiplatelet agents are pivotal for prevention of coronary artery disease and cerebrovascular disease worldwide. Individual patient data meta-analysis indicates that low-dose aspirin causes a 10% risk reduction in pre-eclampsia for women at high individual risk. However, in the last 15 years it has emerged that a significant proportion of aspirin-treated individuals exhibit suboptimal platelet response, determined biochemically and clinically, termed 'aspirin non-responsiveness', 'aspirin resistance' and 'aspirin treatment failure'. More recently, investigation of aspirin responsiveness has begun in pregnant women. This review explores the history and clinical relevance of 'aspirin resistance' applied to high-risk obstetric populations. Is 'aspirin resistance' clinically relevant in high-risk obstetrics?
Medical subject headings
- Aspirin
- Bleeding Time
- Drug Resistance
- Medication Adherence
- Platelet Aggregation Inhibitors
- Pre-Eclampsia