Mannose Receptor Is Required for Optimal Induction of Vaccine-Induced T-Helper Type 17 Cells and Resistance to Blastomyces dermatitidis Infection.
basic_science · Level V
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- Record sourced from PubMed, PMID 26931447.
- Also identified by DOI 10.1093/infdis/jiw010 and PMC identifier 4857467.
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Abstract
We investigated how innate sensing by the mannose receptor (MR) influences the development of antifungal immunity. We demonstrate that MR senses mannan on the surface of attenuated Blastomyces dermatitidis vaccine yeast and that MR(-/-) mice demonstrate impaired vaccine immunity against lethal experimental blastomycosis, compared with wild-type control mice. Using naive Blastomyces-specific transgenic CD4(+) T cells, we found that MR regulates differentiation of naive T cells into T-helper type 17 (Th17) effector cells, which are essential in vaccine immunity against systemic dimorphic fungi. Thus, MR regulates differentiation of Th17 cells and is required to induce vaccine immunity against lethal pulmonary blastomycosis.
Medical subject headings
- Blastomyces
- Blastomycosis
- Fungal Vaccines
- Lectins, C-Type
- Mannose-Binding Lectins
- Receptors, Cell Surface
- Th17 Cells