Detection of a Novel gyrB Mutation Associated With Fluoroquinolone-Nonsusceptible Salmonella enterica serovar Typhimurium Isolated From a Bloodstream Infection in Ghana.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 26933021.
- Also identified by DOI 10.1093/cid/civ790.
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Abstract
A multidrug-resistant Salmonella enterica serovar Typhimurium with reduced susceptibility to ciprofloxacin was isolated from the blood of a hospitalized child in Ghana. DNA sequencing identified a novel gyrB mutation at codon 466 (Glu466Asp). An increase in fluoroquinolone susceptibility after the introduction of a wild-type gyrB(+) allele demonstrated that the gyrB466 mutation had a direct effect on fluoroquinolone susceptibility.
Medical subject headings
- Bacteremia
- Bacterial Proteins
- DNA Gyrase
- Drug Resistance, Bacterial
- Fluoroquinolones
- Salmonella Infections
- Salmonella typhimurium