Connective tissue diseases: Mitochondria drive NETosis and inflammation in SLE.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 26935279.
- Also identified by DOI 10.1038/nrrheum.2016.24.
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Abstract
Mitochondria are the powerhouses of the cell, providing energy through oxidative respiration. Possibly owing to their similarities with bacteria, however, mitochondria extruded from cells promote inflammation. New research demonstrates that in systemic lupus erythematosus, mitochondrial respiration is critical in neutrophil extracellular trap formation, and that mitochondria released by neutrophils induce inflammatory cytokine production.
Medical subject headings
- DNA, Mitochondrial
- Extracellular Traps
- Granulomatous Disease, Chronic
- Lupus Erythematosus, Systemic
- Mitochondria
- Neutrophils