Steroidal Saponins from the Rhizomes of Aspidistra typica.
Level V
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- Record sourced from PubMed, PMID 26937954.
- Also identified by DOI 10.1371/journal.pone.0150595 and PMC identifier 4777403.
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Abstract
Eleven new furostanol saponins, typaspidosides B-L (1-11), one new spirostanol saponin, typaspidoside M (12), and five known spirostanol saponins, 25S-atropuroside (13), neoaspidistrin (14), (25S)-pratioside D1 (15), 25S-aspidistrin (16) and 25S-neosibiricoside (17) were isolated from the rhizomes of Aspidistra typica Baill. The structures of the new compounds were established using 1D and 2D NMR (1H-1H COSY, HMQC, HMBC and ROESY) spectroscopy, high resolution mass spectrometry, and chemical methods. The aglycones of 1-3 (unusual furostanol saponins with opened E ring type), 9 and 10 (the methoxyl substituent at C-23 position) were found, identified from natural products for the first time. Moreover, the anti-HIV activities of the isolated steroidal glycosides were assessed, and compounds 13, 14, 16 and 17 exhibited high active against HIV-1.
Medical subject headings
- Anti-HIV Agents
- HIV-1
- Liliaceae
- Reassortant Viruses
- Rhizome
- Saponins
- Sterols