Light-Activated Hypoxia-Responsive Nanocarriers for Enhanced Anticancer Therapy.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26948067.
- Also identified by DOI 10.1002/adma.201505869 and PMC identifier 4998838.
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Abstract
A light-activated hypoxia-responsive conjugated polymer-based nanocarrier is developed for efficiently producing singlet oxygen ((1) O2 ) and inducing hypoxia to promote release of its cargoes in tumor cells, leading to enhanced antitumor efficacy. This dual-responsive nanocarrier provides an innovative design guideline for enhancing traditional photodynamic therapeutic efficacy integrated with a controlled drug-release modality.
Medical subject headings
- Antineoplastic Agents
- Drug Carriers
- Light
- Nanoparticles