TGF-β1-induced transcription factor networks in Langerhans cell development and maintenance.
review · Level V
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- Record sourced from PubMed, PMID 26948524.
- Also identified by DOI 10.1111/all.12871 and PMC identifier 5016192.
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Abstract
Langerhans cells (LC) represent a specialized subset of evolutionarily conserved dendritic cells (DC) that populate stratified epithelial tissues, which are essential for the induction of skin and mucosal immunity and tolerance, including allergy. Transforming growth factor-β1 (TGF-β1) has been confirmed to be a predominant factor involved in LC development. Despite great advances in the understanding of LC ontogeny and diverse replenishment patterns, the underlying molecular mechanisms remain elusive. This review focuses on the recent discoveries in TGF-β1-mediated LC development and maintenance, with special attention to the involved transcription factors and related regulators.
Medical subject headings
- Langerhans Cells
- Transcription Factors
- Transforming Growth Factor beta1