Toward a Molecular Definition of Leucine-Dependent mTORC1 Activation.
basic_science · Level V
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- Record sourced from PubMed, PMID 26959180.
- Also identified by DOI 10.1016/j.cmet.2016.02.012.
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Abstract
The mechanistic target of rapamycin complex 1 (mTORC1) coordinates nutrient availability with cell growth. Recent reports by Sabatini and coworkers (Saxton et al., 2016; Wolfson et al., 2016) characterize a cytoplasmic amino acid receptor that couples the binding of leucine to the activation of mTORC1.