Pathway Implications of Aberrant Global Methylation in Adrenocortical Cancer.
Where this comes from
- Record sourced from PubMed, PMID 26963385.
- Also identified by DOI 10.1371/journal.pone.0150629 and PMC identifier 4786116.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
CONTEXT: Adrenocortical carcinomas (ACC) are a rare tumor type with a poor five-year survival rate and limited treatment options. OBJECTIVE: Understanding of the molecular pathogenesis of this disease has been aided by genomic analyses highlighting alterations in TP53, WNT, and IGF signaling pathways. Further elucidation is needed to reveal therapeutically actionable targets in ACC. DESIGN: In this study, global DNA methylation levels were assessed by the Infinium HumanMethylation450 BeadChip Array on 18 ACC tumors and 6 normal adrenal tissues. A new, non-linear correlation approach, the discretization method, assessed the relationship between DNA methylation/gene expression across ACC tumors. RESULTS: This correlation analysis revealed epigenetic regulation of genes known to modulate TP53, WNT, and IGF signaling, as well as silencing of the tumor suppressor MARCKS, previously unreported in ACC. CONCLUSIONS: DNA methylation may regulate genes known to play a role in ACC pathogenesis as well as known tumor suppressors.
Medical subject headings
- Adrenal Cortex Neoplasms
- Adrenocortical Carcinoma
- DNA Methylation
- DNA, Neoplasm
- Gene Expression Regulation, Neoplastic
- Neoplasm Proteins
- Signal Transduction