IL-17-producing γδ T cells enhance bone regeneration.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26965320.
- Also identified by DOI 10.1038/ncomms10928 and PMC identifier 4792964.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Immune responses are crucial not only for host defence against pathogens but also for tissue maintenance and repair after injury. Lymphocytes are involved in the healing process after tissue injury, including bone fracture and muscle damage. However, the specific immune cell subsets and mediators of healing are not entirely clear. Here we show that γδ T cells produce IL-17A, which promotes bone formation and facilitates bone fracture healing. Repair is impaired in IL-17A-deficient mice due to a defect in osteoblastic bone formation. IL-17A accelerates bone formation by stimulating the proliferation and osteoblastic differentiation of mesenchymal progenitor cells. This study identifies a novel role for IL-17-producing γδ T cells in skeletal tissue regeneration.
Medical subject headings
- Bone Regeneration
- Femoral Fractures
- Femur
- Fracture Healing
- Interleukin-17
- Osteogenesis
- T-Lymphocytes