Multiple Subsets of Brain Tumor Initiating Cells Coexist in Glioblastoma.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26991945.
- Also identified by DOI 10.1002/stem.2359.
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Abstract
Brain tumor-initiating cells (BTICs) are self-renewing multipotent cells critical for tumor maintenance and growth. Using single-cell microfluidic profiling, we identified multiple subpopulations of BTICs coexisting in human glioblastoma, characterized by distinct surface marker expression and single-cell molecular profiles relating to divergent bulk tissue molecular subtypes. These data suggest BTIC subpopulation heterogeneity as an underlying source of intra-tumoral bulk tissue molecular heterogeneity, and will support future studies into BTIC subpopulation-specific therapies. Stem Cells 2016;34:1702-1707.
Medical subject headings
- Brain Neoplasms
- Glioblastoma
- Neoplastic Stem Cells