Directed Assembly and Development of Material-Free Tissues with Complex Architectures.

Vrij, Erik; Rouwkema, Jeroen; LaPointe, Vanessa; van Blitterswijk, Clemens; Truckenmüller, Roman; Rivron, Nicolas · Adv Mater · 2016

basic_science · Level V

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Abstract

Material-free tissues are assembled using solely cells. Microstructured hydrogel templates and high content screening allow the formation of centimeter-scale tissues with precise architectures. Similar to developing tissues, these contract autonomously, controllably shift shape, self-scaffold by secreting extracellular matrix, and undergo morphogenesis.

Medical subject headings