Inflammation: Species-specific TLR signalling -- insight into human disease.
Level V
Where this comes from
- Record sourced from PubMed, PMID 27006311.
- Also identified by DOI 10.1038/nrrheum.2016.36 and PMC identifier 4955569.
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Abstract
The selective utilization of IRAK kinases, which are thought to be recruited to MyD88 to form the ‘Myddosome’, has been shown to differ substantially in mouse and human cells. This finding has important implications for the development of therapeutics for inflammatory and autoimmune disorders associated with Toll-like receptors.
Medical subject headings
- Interleukin-1 Receptor-Associated Kinases
- Signal Transduction