How drug resistance takes shape.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 27010172.
- Also identified by DOI 10.7554/eLife.14973 and PMC identifier 4821798.
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Abstract
Mutations in a hormone receptor can lead to therapeutic resistance by making it less able to bind and respond to hormone blocking drugs and by making it active, even when the hormome is not present.
Medical subject headings
- Drug Resistance, Neoplasm
- Selective Estrogen Receptor Modulators