CASTORing New Light on Amino Acid Sensing.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27015302.
- Also identified by DOI 10.1016/j.cell.2016.03.002.
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Abstract
The activation state of mTORC1, a master regulator of cell growth, is particularly sensitive to changes in the intracellular levels of the amino acid arginine, but the sensing mechanisms are poorly understood. In this issue of Cell, Chantranupong et al. identify CASTOR1 as a direct arginine sensor that acts through the GATOR2 complex to regulate mTORC1.
Medical subject headings
- Amino Acids
- Signal Transduction