Concise Review: Advances in Generating Hepatocytes from Pluripotent Stem Cells for Translational Medicine.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 27015786.
- Also identified by DOI 10.1002/stem.2368 and PMC identifier 4982058.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The liver is one of the major organs in the human body. Severe or prolonged exposure of the liver to different factors may cause life-threatening disease, which necessitates donor organ transplantation. While orthotopic liver transplantation can be used to effectively treat liver failure, it is an invasive procedure, which is severely limited by organ donation. Therefore, alternative sources of liver support have been proposed and studied. This includes the use of pluripotent stem cell-derived hepatocytes as a renewable source of cells for therapy. In addition to cell-based therapies, in vitro engineered liver tissue provides powerful models for human drug discovery and disease modeling. This review focuses on the generation of hepatocyte-like cells from pluripotent stem cells and their application in translational medicine. Stem Cells 2016;34:1421-1426.
Medical subject headings
- Hepatocytes
- Pluripotent Stem Cells
- Translational Research, Biomedical