Efficient Purification and Release of Circulating Tumor Cells by Synergistic Effect of Biomarker and SiO2 @Gel-Microbead-Based Size Difference Amplification.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27028055.
- Also identified by DOI 10.1002/adhm.201500981.
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Abstract
Microfluidics-based circulating tumor cell (CTC) isolation is achieved by using gelatin-coated silica microbeads conjugated to CTC-specific antibodies. Bead-binding selectively enlarges target cell size, providing efficient high-purity capture. CTCs captured can be further released non-invasively. This stratagem enables high-performance CTC isolation for subsequent studies.
Medical subject headings
- Antibodies, Neoplasm
- Biomarkers, Tumor
- Cell Separation
- Lab-On-A-Chip Devices
- Microspheres
- Neoplastic Cells, Circulating
- Silicon Dioxide