The "neuro" of neuroblastoma: Neuroblastoma as a neurodevelopmental disorder.
review · Level V
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- Record sourced from PubMed, PMID 27043043.
- Also identified by DOI 10.1002/ana.24659 and PMC identifier 5419586.
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Abstract
Neuroblastoma is a childhood cancer derived from cells of neural crest origin. The hallmarks of its enigmatic character include its propensity for spontaneous regression under some circumstances and its association with paraneoplastic opsoclonus, myoclonus, and ataxia. The neurodevelopmental underpinnings of its origins may provide important clues for development of novel therapeutic and preventive agents for this frequently fatal malignancy and for the associated paraneoplastic syndromes. Ann Neurol 2016;80:13-23.
Medical subject headings
- Neural Crest
- Neuroblastoma
- Neurodevelopmental Disorders