ASK1 signalling regulates brown and beige adipocyte function.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27045525.
- Also identified by DOI 10.1038/ncomms11158 and PMC identifier 4822029.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Recent studies suggest that adult humans have active brown or beige adipocytes, the activation of which might be a therapeutic strategy for the treatment of diverse metabolic diseases. Here we show that the protein kinase ASK1 regulates brown and beige adipocytes function. In brown or white adipocytes, the PKA-ASK1-p38 axis is activated in response to cAMP signalling and contributes to the cell-autonomous induction of genes, including Ucp1. Global and fat-specific ASK1 deficiency leads to impaired metabolic responses, including thermogenesis and oxygen consumption, at the cell and whole-body levels, respectively. Our data thus indicate that the ASK1 signalling axis is a regulator of brown and beige adipocyte gene expression and function.
Medical subject headings
- Adipocytes, Brown
- Adipose Tissue, Brown
- MAP Kinase Kinase Kinase 5
- Signal Transduction
- Thermogenesis