The influence of VKORC1 and CYP2C9 mutations on warfarin response after total hip and knee arthroplasty.
retrospective_cohort · Level III
Where this comes from
- Record sourced from PubMed, PMID 27047214.
- Also identified by DOI 10.1016/j.jor.2015.10.023 and PMC identifier 4796661.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
This study characterizes the influence of genotype at two loci on warfarin response after arthroplasty. 121 postarthroplasty patients given warfarin thromboprophylaxis were reviewed for international normalized ratio (INR) values on the first three days postoperatively. Significant differences among genotypes in INR values on each of the first three postoperative days were assessed. Wild-type patients at both loci (∼23% of patients) had yet to reach therapeutic INR (1.5-2.0) by postoperative day three more frequently than those with a mutation conferring hyper-responsiveness (61% vs. 30%; P ≤ .01). Wild-type patients are not anticoagulated in a sufficiently prompt manner after arthroplasty.
Anatomy
- hip
- knee