Radiological and histopathological examination of apparent lytic lesions in allograft long bones-No cause for concern.

Kent, Mike; Brooker, Greg; Fisher, Ryan; Goh, Geraldine; Aguiar, Ranieri Falcao; Papadimitriou, John; Wong, Daniel; Carey-Smith, Richard et al. · J Orthop · 2015

case_series · Level IV

Where this comes from

Abstract

Identify the nature of apparent lytic lesions within human allograft specimens from patients with no known malignancy, using radiological and histopathological analysis. 123 Post-retrieval radiographs from 23 donors were examined. Sixty-seven radiographs were noted to show apparent lytic lesions. The number, size, character and position of the apparent lesions were recorded. CT scanning of 9 specimens confirmed the lesions to be of air pockets causing artefact. Histopathological analysis showed no malignant or pathological process. Apparent lesions were not pathological. Specimens with similar appearances, in donors with no malignancy, can be safely used in donation.