A Novel Prioritization Method in Identifying Recurrent Venous Thromboembolism-Related Genes.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 27050193.
- Also identified by DOI 10.1371/journal.pone.0153006 and PMC identifier 4822849.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Identifying the genes involved in venous thromboembolism (VTE) recurrence is important not only for understanding the pathogenesis but also for discovering the therapeutic targets. We proposed a novel prioritization method called Function-Interaction-Pearson (FIP) by creating gene-disease similarity scores to prioritize candidate genes underling VTE. The scores were calculated by integrating and optimizing three types of resources including gene expression, gene ontology and protein-protein interaction. As a result, 124 out of top 200 prioritized candidate genes had been confirmed in literature, among which there were 34 antithrombotic drug targets. Compared with two well-known gene prioritization tools Endeavour and ToppNet, FIP was shown to have better performance. The approach provides a valuable alternative for drug targets discovery and disease therapy.
Medical subject headings
- Genetic Predisposition to Disease
- Venous Thromboembolism