Seminal HIV-1 RNA Detection in Heterosexual African Men Initiating Antiretroviral Therapy.
rct · Level II
Where this comes from
- Record sourced from PubMed, PMID 27053765.
- Also identified by DOI 10.1093/infdis/jiw131 and PMC identifier 4918825.
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Abstract
Intermittent shedding of human immunodeficiency virus type 1 (HIV) in semen occurs despite effective antiretroviral therapy (ART) and suppressed blood HIV-1 RNA levels. We assessed the frequency, magnitude, and correlates of seminal HIV-1 RNA shedding in HIV-1-infected African men initiating ART. Seminal HIV-1 RNA was detected in 24% (37 of 155), 10% (5 of 49), and 11% (8 of 70) of samples collected 0-3, 4-6, and >6 months after ART initiation. When blood HIV-1 levels were suppressed, seminal HIV-1 RNA was detected in 8% (16 of 195), and 82% (13 of 16) had an HIV-1 RNA load of < 1000 copies/mL. Seminal HIV-1 RNA shedding was infrequent and present at low levels in HIV-1-infected African men with suppressed blood HIV-1 RNA.
Medical subject headings
- HIV Infections
- RNA, Viral
- Semen
- Virus Shedding