Combination Cancer Therapies with Immune Checkpoint Blockade: Convergence on Interferon Signaling.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 27058661.
- Also identified by DOI 10.1016/j.cell.2016.03.031.
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Abstract
Improving efficacy of immune checkpoint blockade for cancer can be facilitated by combining these agents with each other and/or with other conventional or targeted therapies. Interferon and innate immune signaling pathways in immune and tumor cells have emerged as intriguing determinants of response and resistance, often in complex and seemingly paradoxical ways.
Medical subject headings
- Interferons
- Neoplasms
- Signal Transduction