Early Evidence of Impact of Monovalent Rotavirus Vaccine in Togo.

Tsolenyanu, Enyonam; Mwenda, Jason M; Dagnra, Anoumou; Leshem, Eyal; Godonou, Mawussi; Nassoury, Ibrahim; Landoh, Dadja; Tate, Jacqueline E et al. · Clin Infect Dis · 2016

retrospective_cohort · Level III

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Abstract

Togo introduced monovalent rotavirus vaccine starting 19 June 2014. We compared all-cause acute gastroenteritis (AGE) hospitalizations and rotavirus-associated hospitalizations during the prevaccine period (July 2008-June 2014) to 1 year after vaccine introduction (July 2014-June 2015). The proportion of children with AGE who tested positive for rotavirus declined from 53% (645/1223) in prevaccine years to 36% (68/187) in the postvaccine year (P< .01). The decline only occurred in children <1 year of age who were eligible for vaccination and was greatest during the rotavirus season months, supporting that it was associated with vaccine implementation.

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