A Janus Mucoadhesive and Omniphobic Device for Gastrointestinal Retention.

Lee, Young-Ah Lucy; Zhang, Shiyi; Lin, Jiaqi; Langer, Robert; Traverso, Giovanni · Adv Healthc Mater · 2016

basic_science · Level V

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Abstract

A novel Janus device with omniphobic and mucoadhesive sides that exhibit the unique capacity for antifouling and extended gastrointestinal retention is fabricated. This system enables repulsion of the food and fluid stream by the luminal-facing omniphobic side and allows attachment to the gastrointestinal mucosa by the mucoadhesive side.

Medical subject headings