In experimental chronic kidney disease or cancer, parathyroid hormone is a novel mediator of cachexia.

Wyatt, Christina M; Mitch, William E · Kidney Int · 2016

other · Level V

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Abstract

Hyperparathyroidism plays a central role in the disordered bone mineral metabolism of chronic kidney disease, and has been associated with increased cardiovascular morbidity and mortality in that setting. A recent study suggests a novel role for parathyroid hormone and its receptor in muscle wasting and cachexia occurring in advanced chronic kidney disease.

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