Interleukin-25 Mediated Induction of Angiogenin-4 Is Interleukin-13 Dependent.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27089535.
- Also identified by DOI 10.1371/journal.pone.0153572 and PMC identifier 4835063.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The intestinal surface is directly exposed to both commensal microorganisms as well as pathogens with a single layer of epithelium separating luminal microorganisms from internal tissues. Antimicrobial peptides play a crucial role in allowing epithelial cells to contain in the lumen beneficial and pathogenic microorganisms. The commensal dependent, epithelial produced, Th2 cytokine IL-25 can induce IL-13 and potentially the antimicrobial peptide angiogenin-4. Here we show that IL-13 downstream of IL-25 is required to induce angiogenin-4. IL-25 mediated induction of angiogenin-4 is furthermore not dependent on IL-22 or IL-17.
Medical subject headings
- Epithelial Cells
- Gene Expression Regulation
- Interleukin-13
- Interleukins
- Intestinal Mucosa
- Ribonuclease, Pancreatic