The neurogenetics of alternative splicing.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 27094079.
- Also identified by DOI 10.1038/nrn.2016.27 and PMC identifier 4861142.
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Abstract
Alternative precursor-mRNA splicing is a key mechanism for regulating gene expression in mammals and is controlled by specialized RNA-binding proteins. The misregulation of splicing is implicated in multiple neurological disorders. We describe recent mouse genetic studies of alternative splicing that reveal its critical role in both neuronal development and the function of mature neurons. We discuss the challenges in understanding the extensive genetic programmes controlled by proteins that regulate splicing, both during development and in the adult brain.
Medical subject headings
- Alternative Splicing
- Neurogenesis
- Neurons