Comparative In Vivo Effects of Hemoglobin-Based Oxygen Carriers (HBOC) with Varying Prooxidant and Physiological Reactivity.
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Where this comes from
- Record sourced from PubMed, PMID 27097326.
- Also identified by DOI 10.1371/journal.pone.0153909 and PMC identifier 4838227.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
A series of hemoglobin-based oxygen carrier candidates (HBOC), previously noted for their differences in prooxidative and physiological reactivity, were compared in terms of the negative effects displayed upon injection in Wistar rats. At the concentrations tested, antioxidant strategies based on albumin as well as based on rubrerythrin appear to offer observable physiological advantages.
Medical subject headings
- Blood Substitutes
- Hemoglobins
- Reactive Oxygen Species