Developing Precisely Defined Drug-Loaded Nanoparticles by Ring-Opening Polymerization of a Paclitaxel Prodrug.
basic_science · Level V
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- Record sourced from PubMed, PMID 27111757.
- Also identified by DOI 10.1002/adhm.201600230 and PMC identifier 5279999.
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Abstract
Nanoparticles with high paclitaxel (PTX) loading and low systemic toxicity are prepared in scalable and versatile manner via one-step ring-opening polymerization of a prodrug monomer consisting of PTX that is appended to a cyclic carbonate through a hydrolysable ester linker. Initiating this monomer from a hydrophilic macroinitiator results in an amphiphilic diblock copolymer that spontaneously self-assembles into well-defined nanoparticles with tunable size.
Medical subject headings
- Drug Carriers
- Nanoparticles
- Paclitaxel
- Prodrugs