Discordant Expression of Circulating microRNA from Cellular and Extracellular Sources.
Where this comes from
- Record sourced from PubMed, PMID 27123852.
- Also identified by DOI 10.1371/journal.pone.0153691 and PMC identifier 4849639.
- Licence recorded as CC0.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
MicroRNA (miRNA) expression has rapidly grown into one of the largest fields for disease characterization and development of clinical biomarkers. Consensus is lacking in regards to the optimal sample source or if different circulating sources are concordant. Here, using miRNA measurements from contemporaneously obtained whole blood- and plasma-derived RNA from 2391 individuals, we demonstrate that plasma and blood miRNA levels are divergent and may reflect different biological processes and disease associations.
Medical subject headings
- Biomarkers
- MicroRNAs