Mimicking Tissue Boundaries by Sharp Multiparameter Matrix Interfaces.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27125887.
- Also identified by DOI 10.1002/adhm.201600295.
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Abstract
Engineering interfaces of distinct extracellular compartments mimicking native tissues are key for in-depth in vitro studies on developmental and disease processes in biology and medicine. Sharp interfaces of extracellular matrices are constructed based on fibrillar collagen I networks with a multiparameter control of topology, mechanics, and composition, and their distinct impact on triggering the directionality of cancer cell migration is demonstrated.
Medical subject headings
- Biomimetic Materials
- Cell Movement
- Collagen Type I
- Extracellular Matrix