Successful Prevention of Transmission of Integrase Resistance in the Swiss HIV Cohort Study.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 27130429.
- Also identified by DOI 10.1093/infdis/jiw165.
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Abstract
The prevalence of integrase strand transfer inhibitor (INSTI)-transmitted drug resistance (TDR) may increase with the increasing use of INSTIs. We analyzed the prevalence of INSTI TDR in the Swiss HIV Cohort Study (2008-2014). In 1 of 1316 drug-naive samples (0.1%), a major INSTI TDR mutation was detected. Prevalence was stable, although INSTIs were increasingly used. We showed that this is in contrast to the introduction of previous drug classes, in which more treatment failures with resistant strains occurred and TDR was observed more rapidly. We demonstrated on a population-level that it is possible to avoid TDR to a new drug class for years.
Medical subject headings
- Anti-HIV Agents
- Disease Transmission, Infectious
- Drug Resistance, Viral
- HIV
- HIV Infections
- HIV Integrase