A Mitochondrion-Specific Photoactivatable Fluorescence Turn-On AIE-Based Bioprobe for Localization Super-Resolution Microscope.

Gu, Xinggui; Zhao, Engui; Zhao, Teng; Kang, Miaomiao; Gui, Chen; Lam, Jacky W Y; Du, Shengwang; Loy, Michael M T et al. · Adv Mater · 2016

basic_science · Level V

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Abstract

A novel mitochondrion-specific photo-activatable fluorescence turn-on bioprobe, named as o-TPE-ON+, is designed and readily prepared, operating through a new photoactivatable mechanism of photocyclodehydrogenation. This bioprobe exhibits unique photoactivation behavior in cells, and is applied to super-resolution imaging of mitochondrion and its dynamic investigation in both fixed and live cells under physiological conditions without any external additives.

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