Fusogen-assisted rapid reconstitution of anatomophysiologic continuity of the transected spinal cord.

Abstract

The GEMINI spinal cord fusion protocol exploits the ability of so-called fusogens, such as polyethylene glycol (PEG), to achieve rapid neural restoration of electrical continuity across the ends of a transected spinal cord. Experimental evidence suggests that motor recovery can occur after complete transection of the cervical and dorsal spinal cord in mice and rats following application of PEG. This allows for the possibility of spinal cord "reconstruction" in humans and even the possibility of head transplantation in the future.