Lack of evidence for GDF11 as a rejuvenator of aged skeletal muscle satellite cells.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27139744.
- Also identified by DOI 10.1111/acel.12475 and PMC identifier 4854912.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Recent high-profile studies report GDF11 to be a key circulating 'anti-aging' factor. However, a screen of extracellular proteins attempting to identify factors with 'anti-aging' phenotypes in aged murine skeletal muscle satellite cells did not identify GDF11 activity. We have been unable to confirm the reported activity of GDF11, similar to other laboratories offering conflicting data and describe our attempts to do so in this short take.
Medical subject headings
- Cellular Senescence
- Growth Differentiation Factors
- Satellite Cells, Skeletal Muscle