Triggering bilayer to inverted-hexagonal nanostructure formation by thiol-ene click chemistry on cationic lipids: consequences on gene transfection.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27146355.
- Also identified by DOI 10.1039/c6sm00609d.
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Abstract
The ramification of cationic amphiphiles on their unsaturated lipid chains is readily achieved by using the thiol-ene click reaction triggering the formation of an inverted hexagonal phase (HII). The new ramified cationic lipids exhibit different bio-activities (transfection, toxicity) including higher transfection efficacies on 16HBE 14o-cell lines.
Medical subject headings
- Alkenes
- Drug Carriers
- Lipids
- Nanostructures
- Sulfhydryl Compounds
- Transfection